Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpm
Q-score: 0.505
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Antibody 9.20.1a2 fab (Complex from Homo sapiens)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Antibody 6d6 scfv (25 kDa, Protein from Mus musculus)
- Complex of ebola virus glycoprotein trimer with 1a2 antibody fab and 6d6 antibody scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of lineage II Lassa virus glycoprotein complex (strain NIG08-A41)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8eje
Q-score: 0.391
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp1 (28 kDa, Protein from Lassa mammarenavirus)
Structure of lineage V Lassa virus glycoprotein complex (strain Soromba-R)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8ejf
Q-score: 0.355
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein gp1 (29 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein gp2 (44 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of lineage VII Lassa virus glycoprotein complex (strain Togo/2016/7082)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8ejg
Q-score: 0.429
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8ejj
Q-score: 0.506
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- S370.7 heavy chain fab (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
- S370.7 light chain fab (11 kDa, Protein from Homo sapiens)
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7swd
Q-score: 0.449
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO
Cell (2022) 185 pp. 995-1007.e18 [ DOI: doi:10.1016/j.cell.2022.02.023 Pubmed: 35303429 ]
- Virion spike glycoprotein gp2 (10 kDa, Protein from Zaire ebolavirus)
- 1c3 light chain (12 kDa, Protein from Homo sapiens)
- 1c3 heavy chain (13 kDa, Protein from Homo sapiens)
- Complex of ebov gp lacking the mucin-like-domain with 1c11 scfv and 1c3 fab (300 kDa, Complex from Homo sapiens)
- Virion spike glycoprotein gp1 (31 kDa, Protein from Ebola virus - Gabon (1994-1997))
- 1c11 scfv (26 kDa, Protein from Homo sapiens)
EBOV GP in complex with IgG c2G4 and c13C6 Fabs
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5kel
Q-score: 0.309
Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE, Andersen KG, Saphire EO, Ward AB
Nat Microbiol (2016) 1 pp. 16128-16128 [ DOI: doi:10.1038/nmicrobiol.2016.128 Pubmed: 27562261 ]
- C13c6 variable fab domain heavy chain (13 kDa, Protein from Homo sapiens)
- Ebola surface glycoprotein, gp2 (16 kDa, Protein from Zaire ebolavirus)
- C2g4 variable fab domain heavy chain (13 kDa, Protein from Homo sapiens)
- Ebola surface glycoprotein, gp1 (50 kDa, Protein from Zaire ebolavirus (strain Mayinga-76))
- Ebola virus trimeric surface glycoprotein in complex with igg c2g4 and c13c6 fabs (540 kDa, Complex from Zaire ebolavirus)
- C2g4 variable fab domain light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C13c6 variable fab domain light chain (11 kDa, Protein from Homo sapiens)
EBOV GP in complex with IgG c4G7 and c13C6 Fabs
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5ken
Q-score: 0.185
Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE, Andersen KG, Saphire EO, Ward AB
Nat Microbiol (2016) 1 pp. 16128-16128 [ DOI: doi:10.1038/nmicrobiol.2016.128 Pubmed: 27562261 ]
- C13c6 variable fab domain heavy chain (13 kDa, Protein from Homo sapiens)
- Ebola surface glycoprotein, gp2 (12 kDa, Protein from Zaire ebolavirus (strain Mayinga-76))
- Ebola surface glycoprotein, gp1 (30 kDa, Protein from Zaire ebolavirus)
- Ebola virus trimeric surface glycoprotein in complex with igg c4g7 and c13c6 fabs (540 kDa, Complex)
- C4g7 variable fab domain heavy chain (12 kDa, Protein from Homo sapiens)
- C4g7 variable fab domain light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C13c6 variable fab domain light chain (11 kDa, Protein from Homo sapiens)